Unveiling the Chemical Properties of P2NP: A Key Intermediate in Organic Synthesis


Phenyl-2-nitropropene (P2NP), a yellow-colored compound, has garnered significant attention in the realm of organic synthesis due to its versatility as an intermediate in the preparation of various chemical compounds. Understanding its chemical properties and reactivity is paramount for harnessing its potential in synthetic chemistry.

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Chemical Structure:

  • Molecular Formula: C9H9NO2
  • Chemical Structure:
  • Functional Groups: P2NP contains a phenyl group and a nitro group, conferring distinct chemical properties.

Physical Properties:

  • Appearance: P2NP typically presents as yellow crystals or powder.
  • Melting Point: It exhibits a melting point of insert melting point.
  • Solubility: P2NP is sparingly soluble in water but soluble in organic solvents such as acetone and ethanol.

Chemical Properties:

  • Reactivity: P2NP undergoes various chemical transformations, including reduction to amphetamine derivatives and condensation reactions with amines.
  • Reduction: Reduction of the nitro group in P2NP yields amphetamine or methamphetamine, making it a precursor in the synthesis of these stimulant compounds.
  • Condensation Reactions: P2NP reacts with primary amines to form corresponding imines, a key step in the synthesis of numerous organic compounds.


  • Drug Synthesis: P2NP serves as a crucial intermediate in the synthesis of amphetamine-type stimulants, including methamphetamine and MDMA.
  • Chemical Research: It finds applications as a reagent in chemical research and organic synthesis laboratories.
  • Forensic Analysis: P2NP may be encountered in forensic investigations involving illicit drug manufacturing and trafficking.

Safety Considerations:

  • Toxicity: P2NP exhibits toxicity and should be handled with caution. Exposure to P2NP may cause irritation to the respiratory tract and skin.
  • Regulatory Status: Due to its role in the illicit synthesis of controlled substances, P2NP is subject to regulatory control in many jurisdictions.


Phenyl-2-nitropropene (P2NP) stands as a pivotal intermediate in organic synthesis, particularly in the production of amphetamine-type stimulants. Its diverse chemical properties and reactivity make it a valuable tool for synthetic chemists, albeit with associated safety and regulatory considerations.

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